Protein Details: Aquaporin PIP1-2

Protein ID

ICDB_Pro_0768

Protein Name

Aquaporin PIP1-2

Gene Name

PIP1-2; PIP1B; TMPA; At2g45960; F4I18.6

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

286 amino acids

AlphaFoldDB

AF-Q06611-F1-model_v4.pdb

Function

Water channel required to facilitate the transport of water across cell membrane. Essential for the water permeability of the plasma membrane and for the morphology of the root system. Its function is impaired by Hg(2+). Inhibited by cytosolic acidosis which occurs during anoxia in roots.

Sequence

MEGKEEDVRVGANKFPERQPIGTSAQSDKDYKEPPPAPLFEPGELASWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDNAWDDHWVFWVGPFIGAALAALYHVIVIRAIPFKSRS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Widely expressed; Expressed in roots and above ground.

DOI ID

10.1104/pp.101.4.1397; 10.1007/bf00042352; 10.1038/45471; 10.1111/tpj.13415; 10.1126/science.1088305; 10.1046/j.1365-313x.1996.09010101.x; 10.1073/pnas.97.7.3718; 10.1186/gb-2001-3-1-research0001; 10.1038/nature01853; 10.1074/mcp.m400001-mcp200; 10.1042/bj20060569

RefSeq

NP_182120.1 [Q06611-1]